Every year, millions of people suffer peripheral nerve damage. In the U.S. alone, more than 500,000 people annually require surgery to repair a partially or totally severed peripheral nerve.
Historically, such surgical repair has primarily been accomplished by suturing damaged nerve ends back together or – when the gap between nerve ends is too large – by suturing a nerve graft or synthetic device to the damaged nerve ends. While such suture-based repair has been shown to be relatively effective, it can be time-consuming and tedious, and it has the potential to introduce additional trauma to the nerve being repaired. Thus, there is increasing clinical interest in fast, effective, suture-less techniques.
One such suture-less option is fibrin glue, which has been gaining traction in the U.S. since becoming commercially available in 1998. But, while fibrin glue repair is showing promise in rodent, cadaver, and human studies – especially in terms of procedural efficiency, tensile strength, and minimized secondary damage to the nerve – the technique can still be imprecise, time-consuming, and tedious due to limitations associated with currently available glue application devices.
ZIAN’s Nerve Holder technology was designed to address this opportunity. Via a low profile, minimally-invasive, patent-pending design, the Nerve Holder allows the surgeon to (1) quickly and atraumatically approximate and “hold” the damaged nerve (or graft) ends together, (2) seamlessly dock with existing applicators and uniformly deliver 360-degrees’ worth of glue or gel coverage to the nerve ends (and limit unwanted glue or gel delivery to nearby anatomical structures), (3) cleanly disengage from the nerve ends once they are anastomosed by the cured glue or gel, and (4) efficiently move to close without needing to clean much (if any) glue or gel from non-nerve anatomical structures.
Available for exclusive licensing or acquisition
Initial rat lab study completed with 3D-printed prototypes
Next generation prototype development and validation in progress